Van de Ven Double Ends Everton's Run at Brand New Home Ground
The Dutch defender became the first defender to net twice in a English top-flight game for Tottenham since Jan Vertonghen in March 2013.
At a glance
Micky Van de Ven heads home twice in first half
The home side's Jake O'Brien has goal disallowed after VAR review
Senegalese midfielder scores final goal in dying moments
This loss is the Merseyside club's first at their new ground
Micky van de Ven found the net on two occasions as Tottenham prolonged their winning streak on the road in the top division and delivered Everton their first defeat at their new home.
Everton were unbeaten in their five previous fixtures at their new ground at Bramley-Moore Dock, having departed Goodison Park behind after 133 years at the end of last season.
But Spurs captain Van de Ven pounced twice from corners in the first half to place their strong form at risk, and they were unable to mount a comeback before Pape Matar Sarr - set up by ex-Everton forward Richarlison - nodded in a third to put the game to bed.
Jake O'Brien believed he had levelled the tally a short while after Van de Ven's opener, glancing a bullet header past the Spurs keeper from an Everton corner.
Beto, meanwhile, failed to convert a number of opportunities, while the Italian goalkeeper made a series of excellent saves to ensure Tottenham went five away games unbeaten in the Premier League.
But the video assistant referee intervened, instructing the match official to check the goal on the pitchside monitor and the official decided that the winger and the attacker were in an illegal position and had interfered with the Tottenham goalkeeper.
This victory moves Thomas Frank's team up to third in the division, five points off north London rivals and table-toppers the Gunners.
Everton stay 14th and sit half a dozen points ahead of the drop zone.
Tottenham analysis: Van de Ven excels in duties at each end of pitch
Following a drab midweek display in the Champions League against Monaco, where they mustered a only two shots on target, the manager chose the French striker up front instead of ex-Everton forward Richarlison.
The summer signing was failed to influence the game before being replaced for Richarlison after an hour on the pitch, but it turns out he wasn't needed in the end.
Defender the Dutchman transformed into an offensive threat to be feared.
Spurs' opening strike came from a well-worked set-piece play, with the midfielder directing the ball toward the six-yard box for an free the defender to head home.
And the captain - stepping up as captain in the Argentine's absence - notched his second in added time as he rose above Jordan Pickford to nod in.
Van de Ven was just as outstanding in defence, partnering effectively with his defensive colleague as the duo handled excellently with the 34 crosses thrown their way by the opposition.
Toffees breakdown: Everton missing finishing touch
Everton's new home had been a fortress, but it appears the novelty may have faded somewhat and supporters flocked to the exits after Sarr's third for Spurs.
The end in Everton's unbeaten home run will not be a massive worry for the manager, but their attacking woes are.
The forward and Thierno Barry - the Everton's pair of recognised strikers - had netted just one league goal combined before the weekend's outing.
And they were failed to add to that poor record on a wet and gloomy night on in Liverpool.
Beto's form was summed up when he chose to bicycle-kick a golden opportunity from near the goal, even with having space and opportunity to reposition for a more conventional attempt that would have tested Vicario.
Barry, too, failed to influence the game after coming on for the starter in the 65th minute.
It was not for a shortage of chance. Most of the home side's offensive moves came through the winger and the forward, who relentlessly whipped dangerous balls into the Tottenham penalty area.
Upcoming fixtures for both teams?
Everton: The team travel to the Stadium of Light in the top flight on Monday, 3 November at 20:00 GMT.
Tottenham: The London club go to St James' Park on Wednesday, 29 October for their fourth-round League Cup tie against the Magpies.